CD36 Gene Polymorphism and Susceptibility to Nephropathies
نویسندگان
چکیده
Introduction: Renal diseases affect huge populations in Morocco and abroad. Genetic polymorphisms (SNPs) in scavenger receptors such as CD36 have been implicated in the pathogenesis of diabetes, hypertension, atherosclerosis and cardiovascular diseases. Since CD36 gene expression contributes to these leading causes of kidney disease, we proposed to study the association of two of its polymorphisms to the occurrence of nephropathy. Methods : A population of 130 controls and 132 renal disease patients from the nephrology department of Fez university hospital was analyzed according to clinical parameters and genotyped for two SNPs namely rs1527479 (C > T) and rs1761667 (G > A) in the CD36 gene using polymerase chain reaction and restriction fragment length polymorphism (PCR–RFLP) followed by statistical analysis. Results and discussion: At least one out of the two CD36 gene polymorphisms tested rs1527479 (P1) and rs1761667 (P2) was found in 96.2% of renal patients (45.5% in the homozygous state) and 97.7% of controls (34.6% in the homozygous state). Both polymorphisms (P1 and P2) were present simultaneously in the homozygous state in 38.64% of nephrology patients and only 1.54% of controls (p <0.001). Conclusion: Co-existence of the two polymorphisms rs1527479 (C > T) and rs1761667 (G > A) in the homozygous state would be a powerful predictor of the onset of kidney disease in the Moroccan population.
منابع مشابه
Is human dectin-1 Y238X gene polymorphism related to susceptibility to recurrent vulvovaginal candidiasis?
Background and Purpose: Vulvovaginal candidiasis is a frequent disease affecting approximately more than %75 of all childbearing women at least once in their lifetime by overgrowth of opportunistic Candida species. Recurrent vulvovaginal candidiasis (RVVC) is common in otherwise healthy individuals. Several risk factors were reported to contribute to RVVC susceptibility. A polymorphism in Decti...
متن کاملPolymorphism of Prion Protein Gene (PRNP) in Iranian Holstein and Two Local Cattle Populations (Golpayegani and Sistani) of Iran
Bovine spongiform encephalopathy (BSE) is a fatal infectious neurodegenerative disease in cattle, characterized by the accumulation of an abnormal, proteaseresistant prion protein (PrPSc) in the brain. BSE is similar to scrapie in sheep and goats and Creuzfeldt-Jakob disease in humans. Susceptibility in cattle hasbeen shown to be under the influence of two polymorphic locations, which are...
متن کاملEvaluation of the relationship between MARCO and CD36 single-nucleotide polymorphisms and susceptibility to pulmonary tuberculosis in a Chinese Han population
BACKGROUND Gene polymorphisms impact greatly on a person's susceptibility to pulmonary tuberculosis (PTB). Macrophage receptor with collagenous structure (MARCO) and CD36 are two scavenger receptors (SRs) that can recognize Mycobacterium tuberculosis (Mtb) and play a key role in tuberculosis infection. Gene polymorphisms of MARCO and CD36 may contribute to tuberculosis risk. METHODS To invest...
متن کاملAssociation between Lymphotoxin (LT-A) Gene Polymorphism and Susceptibility to Chronic Hepatitis C Infection in Iranian Patients
Background & Aims: Hepatitis C virus (HCV) infection is a leading cause of chronic liver disease worldwide. The clearance of the HCV is dependent on cytokines control led by genetic. The purpose of this study was to investigate the impact of Lymphotoxin (LT-A) polymorphism at +252 in susceptibility to chronic hepatitis C. Methods: In this case-control study, 120 individuals infected by HCV and ...
متن کاملGenetic polymorphism of N142D GSTO2 and susceptibility to breast cancer: a meta-analysis
To establish a comprehensive picture of the relationship between glutathione S-transferase omega 2 (GSTO2; MIM: 612314) gene N142D variant (rs. 156697) and breast cancer risk, the present meta-analysis was carried out. Studies published up to July 2012 with information about GSTO2 polymorphism and breast cancer risk were identified using several electronic databases. We identified 4 eligible st...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2015